The effect of restraint stress on the kinetics, magnitude, and isotype of the humoral immune response to influenza virus infection.
Identifieur interne : 003479 ( Main/Exploration ); précédent : 003478; suivant : 003480The effect of restraint stress on the kinetics, magnitude, and isotype of the humoral immune response to influenza virus infection.
Auteurs : N. Feng ; R. Pagniano ; C A Tovar ; R H Bonneau ; R. Glaser ; J F SheridanSource :
- Brain, behavior, and immunity [ 0889-1591 ] ; 1991.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Cinétique, Contention physique, Immunoglobuline A (biosynthèse), Immunoglobuline G (biosynthèse), Isotypes des immunoglobulines (biosynthèse), Modèles biologiques, Mâle, Souris, Souris de lignée C57BL (immunologie), Sous-populations de lymphocytes (immunologie), Stress physiologique (immunologie), Virus de la grippe A (immunologie).
- MESH :
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (biosynthesis), Immunoglobulin A (biosynthesis), Immunoglobulin G (biosynthesis), Immunoglobulin Isotypes (biosynthesis), Influenza A virus (immunology), Kinetics, Lymphocyte Subsets (immunology), Male, Mice, Mice, Inbred C57BL (immunology), Models, Biological, Restraint, Physical, Stress, Physiological (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G, Immunoglobulin Isotypes.
- immunology : Influenza A virus, Lymphocyte Subsets, Mice, Inbred C57BL, Stress, Physiological.
- Animals, Kinetics, Male, Mice, Models, Biological, Restraint, Physical.
Abstract
The stress of physical restraint has been shown to modulate the cellular immune response during a viral infection. We have studied the effects of stress on the humoral immune response during infection by influenza virus. Restraint stress altered the kinetics of the antibody response; seroconversion in the IgG and IgA isotypes was delayed in virus-infected C57BL/6 mice subjected to repeated cycles of physical restraint. However, the magnitude and isotype of the mature antibody response were unaffected during the plateau phase; no significant differences were observed between restrained/infected and nonrestrained/infected mice. Thus, the time during infection at which the antibody response was measured was a significant variable in the study of stress-induced alterations of the host's response to a replicating viral antigen. While restraint stress did not significantly affect the magnitude or class of the humoral response, it did alter the kinetics of response.
DOI: 10.1016/0889-1591(91)90032-6
PubMed: 1777731
Affiliations:
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Le document en format XML
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Pagniano</name></author><author><name sortKey="Tovar, C A" sort="Tovar, C A" uniqKey="Tovar C" first="C A" last="Tovar">C A Tovar</name></author><author><name sortKey="Bonneau, R H" sort="Bonneau, R H" uniqKey="Bonneau R" first="R H" last="Bonneau">R H Bonneau</name></author><author><name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. 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Feng</name><affiliation><nlm:affiliation>Department of Medical Microbiology, Ohio State University College of Medicine, Columbus 43210.</nlm:affiliation><wicri:noCountry code="subField">Columbus 43210</wicri:noCountry></affiliation></author><author><name sortKey="Pagniano, R" sort="Pagniano, R" uniqKey="Pagniano R" first="R" last="Pagniano">R. Pagniano</name></author><author><name sortKey="Tovar, C A" sort="Tovar, C A" uniqKey="Tovar C" first="C A" last="Tovar">C A Tovar</name></author><author><name sortKey="Bonneau, R H" sort="Bonneau, R H" uniqKey="Bonneau R" first="R H" last="Bonneau">R H Bonneau</name></author><author><name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. Glaser</name></author><author><name sortKey="Sheridan, J F" sort="Sheridan, J F" uniqKey="Sheridan J" first="J F" last="Sheridan">J F Sheridan</name></author></analytic><series><title level="j">Brain, behavior, and immunity</title><idno type="ISSN">0889-1591</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (biosynthesis)</term><term>Immunoglobulin A (biosynthesis)</term><term>Immunoglobulin G (biosynthesis)</term><term>Immunoglobulin Isotypes (biosynthesis)</term><term>Influenza A virus (immunology)</term><term>Kinetics</term><term>Lymphocyte Subsets (immunology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL (immunology)</term><term>Models, Biological</term><term>Restraint, Physical</term><term>Stress, Physiological (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Cinétique</term><term>Contention physique</term><term>Immunoglobuline A (biosynthèse)</term><term>Immunoglobuline G (biosynthèse)</term><term>Isotypes des immunoglobulines (biosynthèse)</term><term>Modèles biologiques</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL (immunologie)</term><term>Sous-populations de lymphocytes (immunologie)</term><term>Stress physiologique (immunologie)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Immunoglobulin Isotypes</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline A</term><term>Immunoglobuline G</term><term>Isotypes des immunoglobulines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Souris de lignée C57BL</term><term>Sous-populations de lymphocytes</term><term>Stress physiologique</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Lymphocyte Subsets</term><term>Mice, Inbred C57BL</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Kinetics</term><term>Male</term><term>Mice</term><term>Models, Biological</term><term>Restraint, Physical</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cinétique</term><term>Contention physique</term><term>Modèles biologiques</term><term>Mâle</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The stress of physical restraint has been shown to modulate the cellular immune response during a viral infection. We have studied the effects of stress on the humoral immune response during infection by influenza virus. Restraint stress altered the kinetics of the antibody response; seroconversion in the IgG and IgA isotypes was delayed in virus-infected C57BL/6 mice subjected to repeated cycles of physical restraint. However, the magnitude and isotype of the mature antibody response were unaffected during the plateau phase; no significant differences were observed between restrained/infected and nonrestrained/infected mice. Thus, the time during infection at which the antibody response was measured was a significant variable in the study of stress-induced alterations of the host's response to a replicating viral antigen. While restraint stress did not significantly affect the magnitude or class of the humoral response, it did alter the kinetics of response.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bonneau, R H" sort="Bonneau, R H" uniqKey="Bonneau R" first="R H" last="Bonneau">R H Bonneau</name><name sortKey="Feng, N" sort="Feng, N" uniqKey="Feng N" first="N" last="Feng">N. Feng</name><name sortKey="Glaser, R" sort="Glaser, R" uniqKey="Glaser R" first="R" last="Glaser">R. Glaser</name><name sortKey="Pagniano, R" sort="Pagniano, R" uniqKey="Pagniano R" first="R" last="Pagniano">R. Pagniano</name><name sortKey="Sheridan, J F" sort="Sheridan, J F" uniqKey="Sheridan J" first="J F" last="Sheridan">J F Sheridan</name><name sortKey="Tovar, C A" sort="Tovar, C A" uniqKey="Tovar C" first="C A" last="Tovar">C A Tovar</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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